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A multi‐institutional study to assess adherence to lung stereotactic body radiotherapy planning goals
Author(s) -
Woerner Andrew,
Roeske John C.,
Harkenrider Matthew M.,
Fan John,
Aydogan Bulent,
Koshy Matthew,
Laureckas Robert,
Vali Faisal,
Campana Maria,
Surucu Murat
Publication year - 2015
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4926551
Subject(s) - medicine , cyberknife , nuclear medicine , lung , radiosurgery , radiation treatment planning , radiation therapy , radiology
Purpose: A multi‐institutional planning study was performed to evaluate the frequency that current guidelines established by Radiation Therapy Oncology Group (RTOG) protocols and other literature for lung stereotactic body radiotherapy (SBRT) treatments are followed. Methods: A total of 300 patients receiving lung SBRT treatments in four different institutions were retrospectively reviewed. The treatments were delivered using Linac based SBRT (160 patients) or image guided robotic radiosurgery (140). Most tumors were located peripherally (250/300). Median fractional doses and ranges were 18 Gy (8–20 Gy), 12 Gy (6–15 Gy), and 10 Gy (5–12 Gy) for three, four, and five fraction treatments, respectively. The following planning criteria derived from RTOG trials and the literature were used to evaluate the treatment plans: planning target volumes, PTV V 100 ≥ 95% and PTV V 95 ≥ 99%; conformality indices, CI 100% < 1.2 and CI 50% range of 2.9–5.9 dependent on PTV; total lung‐ITV: V 20Gy < 10%, V 12.5Gy < 15%, and V 5Gy < 37%; contralateral lung V 5Gy < 26%; and maximum doses for spinal cord, esophagus, trachea/bronchus, and heart and great vessels. Populations were grouped by number of fractions, and dosimetric criteria satisfaction rates (CSRs) were reported. Results: Five fraction regimens were the most common lung SBRT fractionation (46%). The median PTV was 27.2 cm 3 (range: 3.8–419.5 cm 3 ). For all plans: mean PTV V 100 was 94.5% (±5.6%, planning CSR: 69.8%), mean PTV V 95 was 98.1% (±4.1%, CSR: 69.5%), mean CI 100% was 1.14 (±0.21, CSR: 79.1%, and 16.5% within minor deviation), and mean CI 50% was 5.63 (±2.8, CSR: 33.0%, and 28.0% within minor deviation). When comparing plans based on location, peripherally located tumors displayed higher PTV V 100 and PTV V 95 CSR (71.5% and 71.9%, respectively) than centrally located tumors (61.2% and 57.1%, respectively). Overall, the planning criteria were met for all the critical structure such as lung, heart, spinal cord, esophagus, and trachea/bronchus for at least 85% of the patients. Conclusions: Among the various parameters that were used to evaluate the SBRT plans, the CI 100% and CI 50% were the most challenging criteria to meet. Although the CSRs of organs at risk were higher among all cases, their proximity to the PTV was a significant factor.