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MO‐A‐BRD‐00: Current Trends in Y90‐Microsphere Therapy: Delivery and Dosimetry
Author(s) -
Kappadath Srinivas Cheenu
Publication year - 2015
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4925265
Subject(s) - dosimetry , radiation therapy , selective internal radiation therapy , radiation treatment planning , medicine , microsphere , nuclear medicine , radionuclide therapy , medical imaging , radiology , medical physics , biomedical engineering , hepatocellular carcinoma , cancer research , chemical engineering , engineering
Yttrium‐90 (Y90) microsphere therapy, a form of radiation therapy, is an increasingly popular option for care of patients with liver metastases or unresectable hepatocellular carcinoma. The therapy directly delivers Y90 microspheres via the hepatic artery to disease sites. Following delivery, a vast majority of microspheres preferentially lodge in the capillary vessels due to their embolic size and targeted trans‐arterial delivery – depositing up to 90% of its energy in the first 5 mm of tissue. There have been a number of advances in tomographic imaging within both interventional radiology and nuclear medicine that has advanced therapy planning techniques. Quantitative imaging of Y90 microsphere distribution post‐therapy has also seen innovations that have led to improvements in tumor dosimetry and characterization of tumor response. A review of current trends and recent innovation in Y90 microsphere therapies will be presented. Learning Objectives: 1. To present the imaging requirements for Y90 microsphere therapy planning 2. To explain the standard dosimetry models used in Y90 microsphere therapy planning 3. To report on advances in imaging for therapy planning and posttherapy assessment of tumor dosimetry and response