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SU‐E‐I‐64: Transverse Relaxation Time in Methylene Protons of Non‐Alcoholic Fatty Liver Disease Rats
Author(s) -
Song KH,
Lee DW,
Choe BY
Publication year - 2015
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4924061
Subject(s) - methylene , imaging phantom , fatty liver , relaxation (psychology) , in vivo , chemistry , nuclear magnetic resonance , magnetic resonance imaging , nuclear medicine , medicine , physics , biology , radiology , microbiology and biotechnology , disease , organic chemistry
Purpose: The aim of this study was to evaluate transverse relaxation time of methylene resonance compared to other lipid resonances. Methods: The examinations were performed using a 3.0 T scanner with a point — resolved spectroscopy (PRESS) sequence. Lipid relaxation time in a lipid phantom filled with canola oil was estimated considering repetition time (TR) as 6000 msec and echo time (TE) as 40 — 550 msec. For in vivo proton magnetic resonance spectroscopy ( 1 H — MRS), eight male Sprague — Dawley rats were given free access to a normal ‐ chow (NC) and eight other male Sprague‐Dawley rats were given free access to a high — fat (HF) diet. Both groups drank water ad libitum. T 2 measurements in the rats’ livers were conducted at a fixed TR of 6000 msec and TE of 40 – 220 msec. Exponential curve fitting quality was calculated through the coefficients of determination (R 2 ). Results: A chemical analysis of phantom and liver was not performed but a T 2 decay curve was acquired. The T 2 relaxation time of methylene resonance was estimated as follows: NC rats, 37.07 ± 4.32 msec; HF rats, 31.43 ± 1.81 msec (p < 0.05). The extrapolated M0 values were higher in HF rats than in NC rats (p < 0.005). Conclusion: This study of 1 H‐MRS led to sufficient spectral resolution and signal — to — noise ratio differences to characterize all observable resonances for yielding T 2 relaxation times of methylene resonance. 1 H — MRS relaxation times may be useful for quantitative characterization of various liver diseases, including fatty liver disease. This study was supported by grant (2012‐007883 and 2014R1A2A1A10050270) from the Mid‐career Researcher Program through the NRF funded by Ministry of Science. In addition, this study was supported by the Industrial R&D of MOTIE/KEIT (10048997, Development of the core technology for integrated therapy devices based on real‐time MRI‐guided tumor tracking).