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Sci—Thur AM: YIS ‐ 02: Radiogenomic Modeling of Normal Tissue Toxicities in Prostate Cancer Patients Receiving Hypofractionated Radiotherapy
Author(s) -
Coates J,
Jeyaseelan K,
Ybarra N,
David M,
Faria S,
Souhami L,
Cury F,
Duclos M,
El Naqa I
Publication year - 2014
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4894887
Subject(s) - medicine , radiation therapy , radiogenomics , single nucleotide polymorphism , receiver operating characteristic , prostate cancer , snp , oncology , nuclear medicine , cancer , radiology , genotype , biology , genetics , gene , radiomics
Inter‐patient radiation sensitivity variability has recently been shown to have a genetic component. This genetic component may play a key role in explaining the fluctuating rates of radiation‐induced toxicities (RITs). Single nucleotide polymorphisms (SNPs) have thus far yielded inconsistent results in delineating RITs while copy number variations (CNVs) have not yet been investigated for such purposes. We explore a radiogenomic modeling approach to investigate the association of CNVs and SNPs, along with clinical and dosimetric variables, in radiation induced rectal bleeding (RB) and erectile dysfunction (ED) in prostate cancer patients treated with curative hypofractionated irradiation. A cohort of 62 prostate cancer patients who underwent hypofractionated radiotherapy (66 Gy in 22 fractions) between 2002 to 2010 were retrospectively genotyped for CNV and SNP rs5489 in the xrcc1 DNA repair gene. Late toxicity rates for RB grade 2 & 3 and grade 3 alone were 29.0% and 12.9%, respectively. ED toxicity was found to be 62.9%. Radiogenomic model performance was evaluated using receiver operating characteristic area under the curve (AUC) and resampling by cross‐validation. Binary variables were evaluated using Chi‐squared contingency table analysis and multivariate models by Spearman's rank correlation coefficient (rs). Ten patients were found to have three copies of xrcc1 CNV (RB: χ 2 =14.6, p<0.001 and ED: χ 2 =4.88, p=0.0272) and twelve had heterozygous rs25489 SNP (RB: χ 2 =0.278, p=0.599 and ED: χ 2 =0.112, p=0.732). Radiogenomic modeling yielded significant, cross‐validated NTCP models for RB (AUC=0.665) and ED (AUC=0.754). These results indicate that CNVs may be potential predictive biomarkers of both late ED and RB.