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SU‐E‐T‐141: Effect of a Single Gold Nanoparticle with Different Sizes Inside a Small Water Phantom
Author(s) -
Jing J,
Lin H,
Xiong Z
Publication year - 2014
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4888471
Subject(s) - electron , imaging phantom , proton , secondary electrons , atomic physics , range (aeronautics) , materials science , particle (ecology) , linear energy transfer , physics , optics , nuclear physics , radiation , composite material , oceanography , geology
Purpose: This study is to investigate the effects of the gold nanoparticles (GNP), a series of micrometre scale simulations have been constructed with Geant4 to track particles and simulate the effects of those particles as they pass through water phantom. Methods: The simulations were used to calculate the number of secondary electrons which are emitted from the particle tracks and the amount of energy which is deposited in the cell tissue. More electrons means that more water molecules can undergo hydrolysis and create potentially dangerous free radical molecules, therefore breaking up DNA and killing off cells or causing damaging mutations. Results: For the 20nm GNP, all three proton energies saw a small increase of electrons above the control, while the X‐rays nearly tripled the number of electrons in the phantom. For the 50 nm GNP, the 3 and 2 MeV protons saw a small increase again, however the 1 MeV protons saw a decrease in electrons, the X‐rays saw a large increase of nearly 4 times the number of electrons. For the 110nm GNP, all three proton energies saw a decrease in the total number of electrons in the phantom, while the X‐rays saw an increase of 8 times as many electrons. Conclusion: From the range of GNP sizes used, it was found that the X‐rays have a larger dose enhancement effect as the GNP size increases, the relation between electron emissions and GNP size was linear. This is because the majority of the dose from the X‐rays is delivered to the cell tissue through the initial high energy secondary electrons, any dose lost from the Augerelectrons being trapped inside the GNP volume is small compared to the dose that escapes with the high energy electrons.