Premium
A super‐resolution ultrasound method for brain vascular mapping
Author(s) -
OˈReilly Meaghan A.,
Hynynen Kullervo
Publication year - 2013
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4823762
Subject(s) - imaging phantom , ultrasound , image resolution , biomedical engineering , materials science , beamforming , medical imaging , neuroimaging , microbubbles , tomography , radiology , medicine , optics , computer science , physics , telecommunications , psychiatry
Purpose: High‐resolution vascular imaging has not been achieved in the brain due to limitations of current clinical imaging modalities. The authors present a method for transcranial ultrasound imaging of single micrometer‐size bubbles within a tube phantom.Methods: Emissions from single bubbles within a tube phantom were mapped through an ex vivo human skull using a sparse hemispherical receiver array and a passive beamforming algorithm. Noninvasive phase and amplitude correction techniques were applied to compensate for the aberrating effects of the skull bone. The positions of the individual bubbles were estimated beyond the diffraction limit of ultrasound to produce a super‐resolution image of the tube phantom, which was compared with microcomputed tomography (micro‐CT).Results: The resulting super‐resolution ultrasound image is comparable to results obtained via the micro‐CT for small tissue specimen imaging.Conclusions: This method provides superior resolution to deep‐tissue contrast ultrasound and has the potential to be extended to provide complete vascular network imaging in the brain.