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MO‐D‐141‐04: Brown Adipose Tissue Uptake Comparison Between Pharmacological and Environmental Control in a Pediatric PET Facility
Author(s) -
Brady S,
Davis W,
Holman T,
Minderman S,
Davis L,
Shulkin B
Publication year - 2013
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4815251
Subject(s) - brown adipose tissue , medicine , mediastinum , sedation , propofol , population , abdomen , nuclear medicine , anesthesia , adipose tissue , thorax (insect anatomy) , surgery , anatomy , environmental health
Purpose: Compare analgesic pharmacology vs. environmental means for controlling FDG uptake in brown adipose tissue (BAT) in a pediatric population with neoplasms. Methods: For two years (2009–2011) patients were sorted into two groups. (1) patients that required relaxation (Versed) or general anesthesia (Propofol); group one received ∼1 hour for uptake in a temperature controlled room before drug administration/scanning. (2) patients were warmed in a temperature controlled room for ∼1 hour prior to FDG injection and for ∼1 hour after injection. Patient images were evaluated for the presence of BAT: (0) no BAT uptake, (1) Less than uptake in the liver, (2) equal to uptake in the liver, and (3) greater than uptake in the liver. BAT uptake was investigated in the: neck (left and right), axilla (left and right), diaphragm, mediastinum, posterior thorax, and abdomen/pelvis. BAT uptake was considered in a patient with at least one anatomical region with a score > 0. Point biserial correlation, assuming dichotomous data, was calculated to determine statistical significance using a one‐sided t‐test. Results: Room temperatures for 623 patients were collected. Mean room temperature over the two years was 74.5° ± 1.3°. A total of 361 patients received sedation/anesthesia drugs. 129 patients were randomly selected; 114 patients (88%) had no BAT uptake and 15 (12%) demonstrated uptake. For group two, 143 patients were randomly selected from the 623. Room temperature for patients with BAT uptake (41%) was 74.4° ± 1.4°, and without BAT uptake (59%) was 75.0° ± 1.1°; a statistically significant difference (t‐value was 1.9, critical number was 1.7). Conclusion: A statistically significant improvement in BAT uptake was found for patients held for one hour in rooms with mean temperatures of 75° prior to FDG injection. BAT was not fully controlled using environmental controls as compared to patients that received analgesic pharmacology.