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A stochastic model of cell survival for high‐Z nanoparticle radiotherapy
Author(s) -
Zygmanski Piotr,
Hoegele Wolfgang,
Tsiamas Panagiotis,
Cifter Fulya,
Ngwa Wil,
Berbeco Ross,
Makrigiorgos Mike,
Sajo Erno
Publication year - 2013
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4773885
Subject(s) - formalism (music) , poisson distribution , population , dosimetry , radiation therapy , stochastic process , stochastic modelling , biological system , mathematics , statistical physics , statistics , physics , medicine , nuclear medicine , biology , surgery , art , musical , environmental health , visual arts
Purpose: The authors present a stochastic framework for the assessment of cell survival in gold nanoparticle radiotherapy.Methods: The authors derive the equations for the effective macroscopic dose enhancement for a population of cells with nonideal distribution of gold nanoparticles (GNP), allowing different number of GNP per cell and different distances with respect to the cellular target. They use the mixed Poisson distribution formalism to model the impact of the aforementioned physical factors on the effective dose enhancement.Results: The authors show relatively large differences in the estimation of cell survival arising from using approximated formulae. They predict degeneration of the cell killing capacity due to different number of GNP per cell and different distances with respect to the cellular target.Conclusions: The presented stochastic framework can be used in interpretation of experimental cell survival or tumor control probability studies.