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A multitarget training method for artificial neural network with application to computer‐aided diagnosis
Author(s) -
Liu Bei,
Jiang Yulei
Publication year - 2013
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4772021
Subject(s) - artificial neural network , artificial intelligence , computer science , pattern recognition (psychology) , computer aided diagnosis , binary number , training (meteorology) , binary classification , breast cancer , computer aided , mammography , class (philosophy) , machine learning , cancer , medicine , mathematics , support vector machine , physics , arithmetic , meteorology , programming language
Purpose: The authors propose a new training method for artificial neural networks (ANNs) in two‐class classification tasks such as classifying breast lesions on a mammogram as malignant or benign.Methods: Whereas the conventional binary training method uses binary training target values based on the diagnostic truth of a lesion being malignant or benign, the authors use multiple training target values based on more detailed histological diagnosis that presumably are related to the posterior probability of a lesion being malignant. The authors performed Monte Carlo simulation studies in which training target values were assigned based on posterior probability, and they also performed a mammography study in which training target values were assigned according to histological subtypes.Results: These studies showed that the multitarget training method produced less variability in the ANN outputs than the binary training method. The simulation studies also showed that except for when the number of training cases was extremely large, the multitarget training method produced improved overall classification performance over the binary training method.Conclusions: Therefore, the multitarget ANN training method is potentially useful for ANN applications in computer‐aided diagnosis of breast cancer.