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MO‐G‐BRB‐01: Rosalyn Yalow: Contributions and Legacy, a Memorial Session
Publication year - 2012
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.4735844
Subject(s) - radioimmunoassay , antibody , positron emission tomography , nuclear medicine , in vivo , medicine , medical physics , positron , pathology , immunology , biology , physics , microbiology and biotechnology , quantum mechanics , electron
Dr. Rosalyn Yalow was a brilliant physicist who co‐developed the technique of radioimmunoassay (RIA). This is a pioneering application of radiotracers in medicine that allows the measurements of the concentration of hundreds of pharmacologic and biologic substances in the blood and in other fluids of the human body. Dr. Yalow's vision has led to the application of radiolabeled antibodies for the quantitative measurement of antigens in vivo through the use of positron emission tomography in combination with tumor specific antibodies labeled with positron emitters. In this presentation, the potential of 124I‐labeled antibodies to target and estimate disease burden will be discussed along with the utility of this information for personalized therapeutic strategies with drugs, radiation and antibodies. Learning Objectives: 1. Learn how the principals of radioimmunoassay could be adapted to in vivo radioimmuno diagnosis. 2. Learn how antibodies labeled with positron emitting isotopes could provide quantitative information on the amount of antigen and therefore tumor cells with a cancer lesion. 3. Learn how radiolabeled antibodies could be used for therapy planning.