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Photoacoustic tomography and fluorescence molecular tomography: A comparative study based on indocyanine green
Author(s) -
Wang Bo,
Zhao Qing,
Barkey Natalie M.,
Morse David L.,
Jiang Huabei
Publication year - 2012
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3700401
Subject(s) - indocyanine green , tomography , photoacoustic tomography , photoacoustic imaging in biomedicine , computed tomography , computed tomography laser mammography , nuclear medicine , positron emission tomography , preclinical imaging , medical physics , medicine , radiology , optics , physics , pathology , in vivo , microbiology and biotechnology , biology
Purpose: Both photoacoustic tomography (PAT) and fluorescence molecular tomography (FMT) can be used for molecular imaging when contrast agents are administrated. The goal of this work is to comparatively evaluate the performance of reflection‐mode PAT and FMT in common phantom when indocyanine green (ICG) was used as a contrast agent.Methods: Reflection‐mode PAT and FMT systems were developed. Target embedded in a background phantom with different ICG concentration, size, and depth location was examined. Comparisons were made in terms of target morphology, spatial resolution, and sensitivity between the two modalities.Results: Phantom results showed that PAT and FMT gave different image morphology. PAT offered higher spatial resolution, while FMT provided higher sensitivity. Thus, improved target detection could be achieved by correlating the complementary information obtained from the two modalities.Conclusions: The combination of high resolution PAT and high sensitivity FMT will provide a more complete range of pathology spectra for more reliable target detection, suggesting a potentially better diagnostic tool when this combination coupled with the administration of ICG as contrast agent is applied to clinical problems in the future.