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Automatic 3D registration of dynamic stress and rest 82 Rb and flurpiridaz F 18 myocardial perfusion PET data for patient motion detection and correction
Author(s) -
Woo Jonghye,
Tamarappoo Balaji,
Dey Damini,
Nakazato Ryo,
Le Meunier Ludovic,
Ramesh Amit,
Lazewatsky Joel,
Germano Guido,
Berman Daniel S.,
Slomka Piotr J.
Publication year - 2011
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3656951
Subject(s) - nuclear medicine , myocardial perfusion imaging , cardiac pet , correction for attenuation , perfusion , positron emission tomography , artificial intelligence , image registration , scanner , perfusion scanning , medicine , computer vision , computer science , radiology , image (mathematics)
Purpose: The authors aimed to develop an image‐based registration scheme to detect and correct patient motion in stress and rest cardiac positron emission tomography (PET)/CT images. The patient motion correction was of primary interest and the effects of patient motion with the use of flurpiridaz F 18 and 82 Rb were demonstrated.Methods: The authors evaluated stress/rest PET myocardial perfusion imaging datasets in 30 patients (60 datasets in total, 21 male and 9 female) using a new perfusion agent (flurpiridaz F 18) ( n = 16) and 82 Rb ( n = 14), acquired on a Siemens Biograph‐64 scanner in list mode. Stress and rest images were reconstructed into 4 ( 82 Rb) or 10 (flurpiridaz F 18) dynamic frames (60 s each) using standard reconstruction (2D attenuation weighted ordered subsets expectation maximization). Patient motion correction was achieved by an image‐based registration scheme optimizing a cost function using modified normalized cross‐correlation that combined global and local features. For comparison, visual scoring of motion was performed on the scale of 0 to 2 (no motion, moderate motion, and large motion) by two experienced observers.Results: The proposed registration technique had a 93% success rate in removing left ventricular motion, as visually assessed. The maximum detected motion extent for stress and rest were 5.2 mm and 4.9 mm for flurpiridaz F 18 perfusion and 3.0 mm and 4.3 mm for 82 Rb perfusion studies, respectively. Motion extent (maximum frame‐to‐frame displacement) obtained for stress and rest were (2.2 ± 1.1, 1.4 ± 0.7, 1.9 ± 1.3) mm and (2.0 ± 1.1, 1.2 ±0 .9, 1.9 ± 0.9) mm for flurpiridaz F 18 perfusion studies and (1.9 ± 0.7, 0.7 ± 0.6, 1.3 ± 0.6) mm and (2.0 ± 0.9, 0.6 ± 0.4, 1.2 ± 1.2) mm for 82 Rb perfusion studies, respectively. A visually detectable patient motion threshold was established to be ≥2.2 mm, corresponding to visual user scores of 1 and 2. After motion correction, the average increases in contrast‐to‐noise ratio (CNR) from all frames for larger than the motion threshold were 16.2% in stress flurpiridaz F 18 and 12.2% in rest flurpiridaz F 18 studies. The average increases in CNR were 4.6% in stress 82 Rb studies and 4.3% in rest 82 Rb studies.Conclusions: Fully automatic motion correction of dynamic PET frames can be performed accurately, potentially allowing improved image quantification of cardiac PET data.