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TU‐A‐BRC‐06: Using Hyperpolarized 13C Magnetic Resonance Spectroscopy to Detect Radiation Induced Lung Injury at an Early Stage
Author(s) -
Thind K,
Ouriadov A,
FeiesenWaldner L,
Chen A,
Scholl T,
Fox M,
Wong E,
VanDyk J,
Hill R,
Hope A,
Santyr G
Publication year - 2011
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3613082
Subject(s) - nuclear magnetic resonance , in vivo , irradiation , nuclear magnetic resonance spectroscopy , nuclear medicine , magnetic resonance imaging , chemistry , lung , spectroscopy , medicine , biology , physics , radiology , microbiology and biotechnology , nuclear physics , quantum mechanics
Purpose: To use hyperpolarized, 13 C Magnetic Resonance Spectroscopy for early detection of Radiation Induced Lung Injury (RILI) by quantifying the ratio between metabolites of, 13 C‐lactate and, 13 C‐pyruvateMethods: Rats were irradiated with dose of 14 Gy to the thorax region to induced RILI using a, 13 Co source. The contrast agent,, 13 C‐pyruvate was hyperpolarized using Dynamic Nuclear Polarization (DNP) that increases signal intensity by four orders of magnitude. It was injected into the animals two weeks post irradiation and dynamic, 13 C‐spectroscopy was performed. Proton Images were acquires prior to the spectroscopy for proper localization of the thorax region. Results: A factor of more than two increase in the, 13 C‐lactate to, 13 C‐ pyruvate ratio was observed for the irradiated rats compared to the normal animals. This result supports the hypothesis that an increase in production of lactate is evident with onset of hypoxia, which is a consequence of RILI. Conclusions: Significantly higher ratio of, 13 C‐lactate to, 13 C‐pyruvate is seen the irradiated animals compared to the normal animals demonstrating the feasibility of using, 13 C pyruvate to probe in in vivo metabolism and its use as an early market for onset of RILI.