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SU‐E‐I‐155: Esophageal Squamous Cell Carcinoma: Relationship Between 18F‐FDG PET‐CT Maximum Standardized Uptake Value, Metabolic Tumour Volume and TNM Classification
Author(s) -
Zhu W,
Sun X,
Xing L,
Yue J,
Qu W,
Yu J
Publication year - 2011
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3611729
Subject(s) - standardized uptake value , stage (stratigraphy) , medicine , positron emission tomography , esophageal cancer , nuclear medicine , esophageal squamous cell carcinoma , ajcc staging system , cancer , t stage , cancer staging , carcinoma , oncology , staging system , biology , paleontology
Purpose: The prognosis for patients with esophageal squamous cell cancer depends on the complex interplay of TNM classifications as well as nonanatomic factors, including histopathologic cell type, histologic grade and cancer location. Few reports have discussed the relationships of both MTV and SUV max measured by PET/CT and stage in esophageal cancer, especially which classified by the last edition staging system. We aimed to evaluate the relationships between primary tumour maximum standardized uptake value, metabolic tumour volume and 7th edition American Joint Committee on Cancer (AJCC) classification in esophageal squmous cell carcinoma (ESCC) patients. Methods: Fluorine‐18 fluorodeoxyglucose positron emission tomography‐computed tomograhy (18F‐FDG PET/CT) scans of 41 consecutive newly diagnosed ESCC patients were retrospectively reviewed. Maximum standard uptake value (SUV max) and metabolic tumour volume (MTV) were recorded. Two‐tailed spearmanˈs correlation was used to analyse the relationships between the metabolic parameters and AJCC stageing system. Results: Positive correlations were observed between SUVmax, MTV and N stage stage (P=0.002, R=0.477; P<0.001, R=0.563) in additon to AJCC stage (P=0.002, R=0.460; P<0.001, R=0.539). Both metabolic parameters were independent variables that significantly affected N stage and AJCC stage by the multiple analysis (P<0.001, adjusted R2=0.348; P=0.002, adjusted R2=0.238), and only SUVmax was independent variables that sinificantly affected T stage (P=0.003, R=0.459; P=0.004, adjusted R2=0.464). Conclusions: The metabolic parameters derived from 18F‐FDG PET/CT were positively correlated with T, N and AJCC stage in primary ESCC. Our findings may suggest a complementary role of these parameters to last 7th edition AJCC staging in prognostication of ESCC patients.