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Prostate cancer characterization on MR images using fractal features
Author(s) -
Lopes R.,
Ayache A.,
Makni N.,
Puech P.,
Villers A.,
Mordon S.,
Betrouni N.
Publication year - 2011
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3521470
Subject(s) - fractal , cancer , prostate cancer , characterization (materials science) , medical imaging , medical physics , artificial intelligence , medicine , nuclear medicine , computer science , mathematics , physics , optics , mathematical analysis
Purpose: Computerized detection of prostate cancer on T2‐weighted MR images. Methods: The authors combined fractal and multifractal features to perform textural analysis of the images. The fractal dimension was computed using the Variance method; the multifractal spectrum was estimated by an adaptation of a multifractional Brownian motion model. Voxels were labeled as tumor/nontumor via nonlinear supervised classification. Two classification algorithms were tested: Support vector machine (SVM) and AdaBoost. Results: Experiments were performed on images from 17 patients. Ground truth was available from histological images. Detection and classification results (sensitivity, specificity) were (83%, 91%) and (85%, 93%) for SVM and AdaBoost, respectively. Conclusions : Classification using the authors' model combining fractal and multifractal features was more accurate than classification using classical texture features (such as Haralick, wavelet, and Gabor filters). Moreover, the method was more robust against signal intensity variations. Although the method was only applied to T2 images, it could be extended to multispectral MR.