Premium
Sci—Fri PM: Delivery— 01: Dosimetry for Microbeam Radiation Therapy at the Canadian Light Source
Author(s) -
Anderson D,
Warkentin B,
Siegbahn EA,
Fallone BG
Publication year - 2010
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3476189
Subject(s) - microbeam , dosimetry , imaging phantom , monte carlo method , synchrotron radiation , synchrotron , nuclear medicine , medical physics , physics , optics , materials science , medicine , mathematics , statistics
Microbeam radiation therapy (MRT) is a novel, experimental radiation therapy technique that uses parallel arrays of microbeams of synchrotron x‐rays. Although the biological mechanism behind MRT is not completely understood, past biological studies have demonstrated an unusually high normal tissue tolerance to dose delivered via microbeams, which is reduced in tumours. In order to establish an experimental MRT program at the Canadian Light Source (CLS), an accurate dosimetric protocol is necessary. As a first step toward this goal the Monte Carlo package PENELOPE is used to calculate dose distributions based on the theoretical energy spectra of the two biomedical beamlines at the CLS. Simulations are based on an array of 25μm wide microbeams, each separated by a distance of 200μm, incident on the surface of a cylindrical water phantom. The lateral dose profiles, and the dose within the microbeam track (peak dose) and the dose between microbeams (valley dose) have been scored as a function of depth. The peak‐to‐valley dose ratio, a metric used to predict the therapeutic efficacy of MRT, and the relative importance of interactions responsible for the dose deposition, have also been obtained, and compared to previously published results from another synchrotron facility. The simulation trends thus far agree with previously published dose distributions, which imply that an experimental MRT program is feasible at the CLS. Upcoming measurements at the CLS will be used to verify our calculations, and will provide the foundation for a dosimetric procedure adequate for MRT animal experimentation.