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Sci—Thur PM: YIS — 05: Hyperpolarized Noble Gas Magnetic Resonance Imaging and Dynamic Spectroscopy of Rat Lungs
Author(s) -
Fox MS,
Ouriadov AV,
Santyr GE
Publication year - 2010
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3476100
Subject(s) - xenon , chemistry , diffusing capacity , noble gas , nuclear magnetic resonance , lung , magnetic resonance imaging , parenchyma , lung volumes , lung function , pathology , medicine , physics , radiology , organic chemistry
Magnetic Resonance (MR) imaging using hyperpolarized noble gases (HNG's), 3 He and 129 Xe, provide non‐invasive approaches for probing lung function and structure. In particular, measurement of HNG ventilated lung volumes (e.g., ventilation defects) and apparent diffusion coefficients (ADC) are useful for characterizing chronic obstructive pulmonary disease (COPD) and emphysema. Of particular interest, hyperpolarized 129 Xe also dissolves in the lung parenchyma and blood compartments, offering an interesting palette of potential biomarkers of pulmonary disease, including quantifying xenon diffusing capacity in inflammatory disease and may be useful for assessing pulmonary perfusion. 129 Xe dissolved in tissue and blood experience large chemical shifts and can be selectively saturated and allowed to recover as a function of delay time as in the chemically selective saturation recovery (CSSR) technique. CSSR has previously been used to study surface‐to‐volume ratio (S/V) and diffusing capacity of xenon (D Xe ) in the lung which is analogous to diffusing capacity of carbon monoxide. In this work, the 129 Xe CSSR technique is used to measure S/V ratios and D xelp in whole healthy rat lungs as a function of ventilated lung volume assessed with 3 He MR imaging. The data follow theoretically predicted trends for T tr , S/V and D XeLP . In parallel to this study, 3D 129 Xe imaging was also investigated and compared to 3 He for lung volume assessment in an effort to remove the reliance on 3 He which is costly and scarce. Absolute ventilated volumes (|VLV|) derived from preliminary results for 3 He and 129 Xe were 9.74 mL and 9.14 mL respectively for a pressure of 9.1cmH 2 O.