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SU‐EE‐A4‐03: Real Time Imaging of the Stopping Distribution for Antiprotons in Biological Targets
Author(s) -
Sellner S,
Caselle M,
Manzari V,
Morel M,
Riedler P,
Welsch C,
Holzscheiter M
Publication year - 2010
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3468026
Subject(s) - physics , antiproton , annihilation , monte carlo method , detector , large hadron collider , nuclear physics , pixel , computational physics , optics , proton , statistics , mathematics
Purpose : To keep the normal tissue complication probability (NTCP) as low as possible, real‐time imaging of the irradiation process is highly desirable to detect and correct any deviation from the treatment plan. Using a simple detector setup, the one‐dimensional annihilation vertex distribution was reconstructed by evaluating the tracks of charged pions resulting from antiproton annihilation in a water phantom. Methods and materials : A spare ladder of 10 silicon pixel detector chips, normally used as part of the vertex detector in the ALICE experiment at CERN, was used. Each chip has 256 × 320 pixels with 50 μm width and 425 μm height, and a thickness of 200 μm. It was mounted unconventionally, allowing charged particles, especially pions, to traverse it more or less tangentially to the front surface, depending on their place of generation. By interacting with a line of pixels, they leave tracks with a specific length and slope, which are used to back‐calculate their origin. FLUKA 2008.3c.0 was used to simulate this set‐up and to generate Monte Carlo data to improve the understanding and analysis of real events collected during a run with 500 MeV/c antiprotons at the antiproton decelerator facility at CERN. Results : Reconstruction of the annihilation vertex was achieved with a resolution of 4 cm in the axial direction, limited by the present detector mounting. Based on Monte Carlo simulations, alternative detector orientations and optimized detector geometries are proposed. Conclusion : The principal applicability of the described method was demonstrated. Further investigation needs to be done to improve on the resolution. Rotating the detector by 90 degrees seems beneficial, but might introduce too much material so that the pions interact significantly, disabling a track reconstruction.