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In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography
Author(s) -
Wang Jia,
Jiang Shudong,
Li Zhongze,
diFlorioAlexander Roberta M.,
Barth Richard J.,
Kaufman Peter A.,
Pogue Brian W.,
Paulsen Keith D.
Publication year - 2010
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3455702
Subject(s) - diffuse optical imaging , optics , breast imaging , tomography , materials science , biomedical engineering , optical tomography , continuous wave , nuclear medicine , detector , breast cancer , in vivo , medicine , cancer , laser , physics , mammography , microbiology and biotechnology , biology
Purpose A NIR tomography system that combines frequency domain (FD) and continuous wave (CW) measurements was used to image normal and malignant breast tissues. Methods FD acquisitions were confined to wavelengths less than 850 nm because of detector limitations, whereas light from longer wavelengths (up to 948 nm) was measured in CW mode with CCD‐coupled spectrometer detection. The two data sets were combined and processed in a single spectrally constrained reconstruction to map concentrations of hemoglobin, water, and lipid, as well as scattering parameters in the breast. Results Chromophore concentrations were imaged in the breasts of nine asymptomatic volunteers to evaluate their intrasubject and intersubject variability. Normal subject data showed physiologically expected trends. Images from three cancer patients indicate that the added CW data is critical to recovering the expected increases in water and decreases in lipid content within malignancies. Contrasts of 1.5 to twofold in hemoglobin and water values were found in cancers. Conclusions In vivo breast imaging with instrumentation that combines FD and CW NIR data acquisition in a single spectral reconstruction produces more accurate hemoglobin, water, and lipid results relative to FD data alone.