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Sci—Fri AM(2): Brachy—05: Compensation of Missed Fractions without Knowledge of Radiobiological Parameters
Author(s) -
Carlone M
Publication year - 2009
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3244197
Subject(s) - radiation therapy , simple (philosophy) , dosimetry , compensation (psychology) , nuclear medicine , mathematics , computer science , medicine , radiology , psychology , philosophy , epistemology , psychoanalysis
Purpose: To develop a simple formula that can be used to estimate the biological effect of missed radiotherapy fractions. Method: A method previously developed by Joiner is applied and extended. Joiner's formulas are re‐derived using an approach which ensures that the α‐type and β‐type damage is held constant in two different fractionation protocols. This same method cannot be used in the case where we would like to compensate for missed radiotherapy fractions; however, this method shows that the BED to the tumour or normal tissue will be within limits that are well defined and simple to calculate. Conclusion: Compensation strategies for missed radiotherapy fractions can be developed, and limits of the resulting BED to both tumour and normal tissue can be calculated using simple formulas. These formulas are independent of radiobiological parameters.