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Sci—Thurs AM: YIS—06: Longitudinal Hyperpolarized 3 He Magnetic Resonance Imaging of Chronic Obstructive Pulmonary Disease
Author(s) -
Kirby M,
Mathew L,
Wheatley A,
McCormack DG,
Parraga G
Publication year - 2009
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3244166
Subject(s) - copd , medicine , magnetic resonance imaging , spirometry , nuclear medicine , pulmonary disease , radiology , asthma
RATIONALE: To date, no studies have quantitatively evaluated chronic obstructive pulmonary disease (COPD) longitudinally using hyperpolarized helium‐3 (3 He ) magnetic resonance imaging (MRI). OBJECTIVES: To evaluate COPD longitudinally using hyperpolarized3 He MRI and to determine correlations between the changes in3 He MRI ventilation defect volume (VDV), apparent diffusion coefficients (ADC) and changes in pulmonary function. METHODS: Hyperpolarized3 He MRI, spirometry and plethysmography were performed in 15 COPD ex‐smokers ( n = 9 stage II and n = 6 stage III/IV COPD) at baseline and 26±2 months later.3 He MRI ADC values were calculated from3 He MRI diffusion‐weighted images and3 He VDV were generated after manual segmentation of3 He MRI spin‐density images. MEASUREMENTS AND MAIN RESULTS: At follow‐up, COPD subjects showed significant increases in3 He MRI CS VDV ( p = .01 ), WL VDV ( p = .04 ), as well as ADC ( p = .003 ) and no significant change in FEV 1( p = .91 ). There was a significant correlation between changes in FEV 1 % predicted and changes in CS VDV ( r = − .66 , p = .007 ), however no significant correlations between smoking history (years non‐smoker at baseline) and changes in3 He MRI measurements or FEV 1was found. CONCLUSIONS: For COPD ex‐smokers,3 He MRI VDV and ADC measurements worsened significantly but there was no significant change in FEV1, suggesting higher sensitivity of hyperpolarized3 He MRI to COPD changes over short periods of time.