Premium
Sensitivity of fluorophore‐quencher labeled microbubbles to externally applied static pressure
Author(s) -
Yuan Baohong
Publication year - 2009
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3158734
Subject(s) - bubble , fluorophore , microbubbles , sensitivity (control systems) , radius , static pressure , materials science , pressure sensor , fluorescence , pressure measurement , chemistry , physics , acoustics , optics , mechanics , thermodynamics , electronic engineering , computer science , ultrasound , computer security , engineering
A fluorophore‐quencher (F‐Q) labeled microbubble system is proposed as a sensor for measuring externally applied static pressure distribution in a tumor. To quantify the sensitivity of such an F‐Q bubble system to the externally applied pressure, a model describing bubble response to the static pressure was derived. Additionally, a model connecting the fluorescence lifetime and bubble radius was developed for the basic F‐Q bubble system. The sensitivity is quantified based on these models given typical parameters. Results show that it is possible to resolve as low as 1 mm Hg pressure variation when both the F‐Q bubble system and the measurement system are optimized. Strategies for optimizing an F‐Q bubble system are discussed.