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Implementation and validation of an ultrasonic tissue characterization technique for quantitative assessment of normal‐tissue toxicity in radiation therapy
Author(s) -
Zhou Jun,
Zhang PengPeng,
Osterman K. Sunshine,
Woodhouse Shermian A.,
Schiff Peter B.,
Yoshida Emi J.,
Lu Zheng Feng,
PileSpellman Eliza R.,
Kutcher Gerald J.,
Liu Tian
Publication year - 2009
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.3103935
Subject(s) - imaging phantom , ultrasonic sensor , materials science , biomedical engineering , dosimetry , reproducibility , calibration , biological tissue , radiation therapy , nuclear medicine , medicine , radiology , mathematics , statistics
The goal of this study was to implement and validate a noninvasive, quantitative ultrasonic technique for accurate and reproducible measurement of normal‐tissue toxicity in radiation therapy. The authors adapted an existing ultrasonic tissue characterization (UTC) technique that used a calibrated 1D spectrum based on region‐of‐interest analysis. They modified the calibration procedure by using a reference phantom instead of a planar reflector. This UTC method utilized ultrasonic radio‐frequency echo signals to generate spectral parameters related to the physical properties (e.g., size, shape, and relative acoustic impedance) of tissue microstructures. Three spectral parameters were investigated for quantification of normal‐tissue injury: Spectral slope, intercept, and midband fit. They conducted a tissue‐mimicking phantom study to verify the reproducibility of UTC measurements and initiated a clinical study of radiation‐induced breast‐tissue toxicity. Spectral parameter values from measurements on two phantoms were reproducible within 1% of each other. Eleven postradiation breast‐cancer patients were studied and significant differences between the irradiated and untreated (contralateral) breasts were observed for spectral intercept ( p = 0.003 ) and midband fit ( p < 0.001 ) but not for slope ( p = 0.14 ) . In comparison to the untreated breast, the average difference in the spectral intercept was 2.99 ± 0.75 dB and the average difference in the midband fit was 3.99 ± 0.65 dB . The preliminary clinical study demonstrated the feasibility of using the quantitative ultrasonic method to evaluate normal‐tissue toxicity in radiation therapy.