Premium
Real‐time sonoelastography of hepatic thermal lesions in a swine model
Author(s) -
Zhang Man,
Castaneda Benjamin,
Christensen Jared,
Saad Wael,
Bylund Kevin,
Hoyt Kenneth,
Strang John G.,
Rubens Deborah J.,
Parker Kevin J.
Publication year - 2008
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2968939
Subject(s) - ultrasound , thermal ablation , medicine , gross examination , elastography , radiology , nuclear medicine , ablation , biomedical engineering , pathology
Sonoelastography has been developed as an ultrasound‐based elasticity imaging technique. In this technique, external vibration is induced into the target tissue. In general, tissue stiffness is inversely proportional to the amplitude of tissue vibration. Imaging tissue vibration will provide the elasticity distribution in the target region. This study investigated the feasibility of using real‐time sonoelastography to detect and estimate the volume of thermal lesions in porcine livers in vivo . A total of 32 thermal lesions with volumes ranging from 0.2 to 5.3cm 3were created using radiofrequency ablation (RFA) or high‐intensity focused ultrasound (HIFU) technique. Lesions were imaged using sonoelastography and coregistered B‐mode ultrasound. Volumes were reconstructed from a sequence of two‐dimensional scans. The comparison of sonoelastographic measurements and pathology findings showed good correlation with respect to the area of the lesions ( r 2 = 0.8823 for RFA lesions,r 2 = 0.9543 for HIFU lesions). In addition, good correspondence was found between three‐dimensional sonoelastography and gross pathology (3.6% underestimate), demonstrating the feasibility of sonoelastography for volume estimation of thermal lesions. These results support that sonoelastography outperforms conventional B‐mode ultrasound and could potentially be used for assessment of thermal therapies.