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Sb 119 —A potent Auger emitter for targeted radionuclide therapy
Author(s) -
Thisgaard H.,
Jensen M.
Publication year - 2008
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2963993
Subject(s) - radionuclide therapy , radionuclide , dosimetry , isotope , nuclear medicine , nuclide , radiochemistry , radiation therapy , cyclotron , imaging phantom , spect imaging , medical physics , medicine , chemistry , nuclear physics , physics , electron , radiology
Auger electron emitting radionuclides in cancer therapy offer the opportunity to deliver a high radiation dose to the tumor cells with high radiotoxicity while minimizing toxicity to normal tissue. We have in this study identified the Auger emitter Sb119 as a potent nuclide for targeted radionuclide therapy based on theoretical dosimetry calculations at a subcellular scale. From these calculations we have determined the cellular S‐values for this therapeutic isotope. Moreover, we have demonstrated the possibility of producing this isotope and also the SPECT‐analogue Sb117 for patient‐specific dosimetry, by measuring the proton irradiation yields for both isotopes using a low‐energy cyclotron. The excellent SPECT imaging properties of the Sb117 radionuclide have been shown by scanning a Jaszczak SPECT Phantom.