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TU‐C‐332‐01: A Comparison of Initial Area Under Curve (IAUC) Obtained From DCE‐CT and ‐MR Imaging in Patients with Cervical Cancer
Author(s) -
Kim S,
Haider M,
Milosevic M,
Maheshwari E,
Yeung I
Publication year - 2008
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2962488
Subject(s) - medicine , nuclear medicine , correlation , area under the curve , area under curve , medical imaging , radiology , mathematics , geometry , pharmacology , pharmacokinetics
Purpose: To compare the IAUC 60 (initial area under curve taken up to 60 seconds) obtained from DCE‐CT and ‐MR imaging in patients with cervical cancer. Method and Materials: A group of 40 patients with cervical cancer received a DCE‐MRI scan followed by a DCE‐CT scan at the time of staging. A radiologist observer identified and contoured the tumours on CT and MR images. At least one slice was identified as the matching slice in the CT and MR images for each patient. IAUC 60 obtained from tumour region was normalized by IAUC 60 from muscle region for DCE‐CT and ‐MR data. Correlation study and Bland‐Altman analysis were performed to assess the relationship between the normalized IAUC 60 obtained from the two imaging modalities. Regression analysis was also applied to assess the relationship between the normalized IAUC 60 and the normalized transfer constant ( rK trans ) for DCE‐CT data. Results: The regression analysis between the normalized IAUC 60 and the normalized transfer constant ( rK trans ) for DCE‐CT data resulted in a significant strong correlation (R = 0.98, P <0.0005). A significant correlation (R = 0.75, P<0.0005) was found in the correlation analysis of the normalized IAUC 60 between DCE‐CT and ‐MR imaging. The Bland‐Altman plot analysis of the normalized IAUC 60 resulted in the 95% limit of agreement ranging from −2.68 to 4.75 and mean difference of 1.03. Since the average of the normalized IAUC 60 measurements from two modalities ranged from 1.81 to 13.73, the degree of agreement was considered to be acceptable for the use of the two modalities interchangeably. Conclusion: The comparison of the normalized IAUC 60 showed that both DCE‐CT and ‐MR imaging modalities may be used interchangeably in assessing cervical cancers. The normalized IAUC 60 may be considered as a reliable quantitative surrogate of the normalized transfer constant for both modalities.