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Technical note: The calibration of Y 90 ‐labeled SIR‐Spheres ® using a nondestructive spectroscopic assay
Author(s) -
Selwyn R.,
Micka J.,
DeWerd L.,
Nickles R.,
Thomadsen B.
Publication year - 2008
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2889621
Subject(s) - dosimetry , spheres , calibration , nuclear medicine , medical physics , medicine , computer science , physics , mathematics , statistics , astronomy
Y90‐labeled SIR‐Spheres ® are currently used to treat patients with hepatic metastases secondary to colorectal adenocarcinoma. In general, the prescribed activity is based on empirical data collected during clinical trials. The activity of the source vial is labeled by the manufacturer as 3.0 GBq ± 10 % and is not independently verified by the end user. This technical note shows that the results of a nondestructive spectroscopic assay of a SIR‐Spheres ® sample was 26% higher than the activity stated by the manufacturer. This difference should not impact the current empirical prescription method but may be problematic for patient‐specific dosimetry applications, such as image‐based dosimetry.