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A deformable phantom for 4D radiotherapy verification: Design and image registration evaluation
Author(s) -
Serban Monica,
Heath Emily,
Stroian Gabriela,
Collins D. Louis,
Seuntjens Jan
Publication year - 2008
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2836417
Subject(s) - imaging phantom , reproducibility , breathing , image registration , biomedical engineering , materials science , piston (optics) , nuclear medicine , computer science , physics , computer vision , optics , medicine , mathematics , image (mathematics) , anatomy , statistics , wavefront
Motion of thoracic tumors with respiration presents a challenge for three‐dimensional (3D) conformal radiation therapy treatment. Validation of techniques aimed at measuring and minimizing the effects of respiratory motion requires a realistic deformable phantom for use as a gold standard. The purpose of this study was to develop and study the characteristics of a reproducible, tissue equivalent, deformable lung phantom. The phantom consists of a Lucite cylinder filled with water containing a latex balloon stuffed with dampened natural sponges. The balloon is attached to a piston that mimics the human diaphragm. Nylon wires and Lucite beads, emulating vascular and bronchial bifurcations, were uniformly glued at various locations throughout the sponges. The phantom is capable of simulating programmed irregular breathing patterns with varying periods and amplitudes. A tissue equivalent tumor, suitable for holding radiochromic film for dose measurements was embedded in the sponge. To assess phantom motion, eight 3D computed tomography data sets of the static phantom were acquired for eight equally spaced positions of the piston. The 3D trajectories of 12 manually chosen point landmarks and the tumor center‐of‐mass were studied. Motion reproducibility tests of the deformed phantom were established on seven repeat scans of three different states of compression. Deformable image registration (DIR) of the extreme breathing phases was performed. The accuracy of the DIR was evaluated by visual inspection of image overlays and quantified by the distance‐to‐agreement (DTA) of manually chosen point landmarks and triangulated surfaces obtained from 3D contoured structures. In initial tests of the phantom, a 20‐mm excursion of the piston resulted in deformations of the balloon of 20 mm superior–inferior, 4 mm anterior–posterior, and 5 mm left–right. The change in the phantom mean lung density ranged from 0.24( 0.12 SD )g / cm 3at peak exhale to 0.19( 0.12 SD )g / cm 3at peak inhale. The SI displacement of the landmarks varied between 94 % and 3 % of the piston excursion for positions closer and farther away from the piston, respectively. The reproducibility of the phantom deformation was within the image resolution( 0.7 × 0.7 × 1.25mm 3 ) . Vector average registration accuracy based on point landmarks was found to be 0.5 (0.4 SD) mm. The tumor and lung mean 3D DTA obtained from triangulated surfaces were 0.4 (0.1 SD) mm and 1.0 (0.8 SD) mm, respectively. This phantom is capable of reproducibly emulating the physically realistic lung features and deformations and has a wide range of potential applications, including four‐dimensional (4D) imaging, evaluation of deformable registration accuracy, 4D planning and dose delivery.