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Comparison of diffuse optical tomography of human breast with whole‐body and breast‐only positron emission tomography
Author(s) -
Konecky Soren D.,
Choe Regine,
Corlu Alper,
Lee Kijoon,
Wiener Rony,
Srinivas Shyam M.,
Saffer Janet R.,
Freifelder Richard,
Karp Joel S.,
Hajjioui Nassim,
Azar Fred,
Yodh Arjun G.
Publication year - 2008
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2826560
Subject(s) - positron emission tomography , diffuse optical imaging , positron emission , nuclear medicine , breast imaging , computed tomography laser mammography , tomography , positron , optical tomography , medicine , physics , preclinical imaging , mammography , radiology , breast cancer , in vivo , microbiology and biotechnology , cancer , quantum mechanics , biology , electron
We acquire and compare three‐dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co‐registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole‐body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose ( F18 ‐ FDG ) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.