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Visualizing localized dynamic changes during epileptic seizure onset in vivo with diffuse optical tomography
Author(s) -
Wang Qiang,
Liang Xiaoping,
Liu Zhao,
Zhang Qizhi,
Carney Paul,
Jiang Huabei
Publication year - 2008
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2818736
Subject(s) - diffuse optical imaging , epilepsy , computed tomography , optical tomography , preclinical imaging , tomography , in vivo , medicine , nuclear magnetic resonance , nuclear medicine , radiology , physics , microbiology and biotechnology , biology , psychiatry
Diffuse optical tomography (DOT) is a promising functional imaging modality due to its ability to provide quantitative and dynamic tomographic imaging of brain functions. This pilot study was conducted to demonstrate that DOT can be used to visualize the changes in local hemodynamics during seizures. The focal seizure was induced by microinjection of 10 μ l of 1.9 mMGABA Aantagonist bicuculline methiodide (BMI) into the left parietal neocortex of male Harlen Sprague–Dawley rats, which was imaged by a multispectral continuous‐wave DOT system. Functional images were obtained by our finite element based image reconstruction algorithm. A series of dynamic 2D images were obtained to delineate the time course of concentration changes of oxyhaemoglobin, deoxyhaemoglobin, and total hemoglobin in the rat brain during seizure onset. The BMI induced epileptic foci were localized and observed over time from the images obtained. Our results suggest that diffuse optical tomography may be a promising modality for epilepsy imaging due to its ability to localize epileptic foci as well as its potential to map the functional activity in the area of human cerebral cortex in planning of epilepsy surgery.