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Hybrid photoacoustic fluorescence molecular tomography using finite‐element‐based inversion
Author(s) -
Razansky Daniel,
Ntziachristos Vasilis
Publication year - 2007
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2786866
Subject(s) - photoacoustic tomography , tomography , iterative reconstruction , optical tomography , diffuse optical imaging , photoacoustic imaging in biomedicine , optics , materials science , finite element method , fluorescence , inverse problem , image quality , absorption (acoustics) , fluorescence lifetime imaging microscopy , reconstruction algorithm , molecular imaging , photoacoustic spectroscopy , biomedical engineering , physics , computer science , image (mathematics) , computer vision , mathematics , in vivo , medicine , mathematical analysis , thermodynamics , microbiology and biotechnology , biology
Improvements in fluorescence reconstruction when utilizing a hybrid photoacoustic (PAT) fluorescence molecular tomography (FMT) method to image optically heterogeneous media are studied and showcased. Quantitative optical absorption maps are retrieved using a normalized backprojection algorithm for PAT reconstruction. Consecutively, the reconstructed absorption distribution is employed into computing a diffusion‐equation‐based forward model for FMT using a finite‐element solution. The potential promise of the suggested method is experimentally verified on tissue‐mimicking fluorescent phantoms, where improvements in the quality of FMT reconstructions are observed when imaging at the presence of a large absorber.