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WE‐D‐M100F‐03: MRI/MRS for Chemo/radiation Therapy Response Assessment
Author(s) -
Jackson E
Publication year - 2007
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2761551
Subject(s) - medicine , in vivo magnetic resonance spectroscopy , magnetic resonance imaging , diffusion mri , radiation therapy , medical physics , clinical trial , dynamic contrast enhanced mri , radiology , nuclear medicine , pathology
Several functional MR techniques, including dynamic contrast agent enhanced MRI (DCE‐MRI), dynamic susceptibility change MRI (DSC‐MRI), diffusion MRI, blood oxygen level dependent (BOLD) MRI, and in vivo spectroscopy, have been proposed and utilized to monitor the effects of conventional and targeted therapies in a longitudinal, non‐invasive manner. This symposium session will briefly review the physical basis of each of these techniques and then will review representative pre‐clinical and clinical trial findings obtained using these methodologies to assess response to treatment by radiation and/or chemotherapy. Objectives: 1. Review the physical basis of DCE‐MRI, DSC‐MRI, diffusion MRI, BOLD MRI, and MR spectroscopy techniques. 2. Review representative applications of the techniques described above to pre‐clinical and clinical trial applications for early assessment of radiation therapy, both as a single regimen as well as in combination with chemotherapeutic and/or targeted therapies.