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TU‐D‐L100F‐01: MR Biomarkers: Current Applications and Unmet Needs
Author(s) -
Jackson E
Publication year - 2007
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2761374
Subject(s) - medical physics , standardization , in vivo magnetic resonance spectroscopy , medicine , clinical trial , diffusion mri , magnetic resonance imaging , diffusion imaging , radiology , computer science , pathology , operating system
The application of MR imaging biomarkers in pre‐clinical studies as well as Phase I/II clinical trials has greatly expanded over the past few years. Such MR biomarkers include measures obtained from dynamic contrast agent enhanced MRI (DCE‐MRI), dynamic susceptibility change MRI (DSC‐MRI), diffusion MRI, blood oxygen level dependent (BOLD) MRI, and in vivo spectroscopy. The symposium session will introduce each of these techniques and provide representative pre‐clinical and clinical trial results using each technique. In addition, more novel applications, such as MR molecular imaging techniques, will be introduced. Finally, a summary of unmet needs of MR imaging biomarkers, specifically the need for standardization, quality control, and change assessment criteria, will be presented. These needs must be addressed in order to Educational Objectives: 1. To understand the physical basis, applications, and current limitations of DCE‐MRI, DSC‐MRI, diffusion MRI, BOLD MRI, and MR spectroscopy techniques currently employed to obtain non‐invasive MR biomarkers. 2. To understand the need for standardization, quality control, and change assessment tools/criteria development.