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Ultrasonic tissue characterization via 2‐D spectrum analysis: Theory and in vitro measurements
Author(s) -
Liu Tian,
Lizzi Frederic L.,
Ketterling Jeffrey A.,
Silverman Ronald H.,
Kutcher Gerald J.
Publication year - 2007
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2436978
Subject(s) - ultrasonic sensor , characterization (materials science) , imaging phantom , materials science , ultrasound , acoustic impedance , biomedical engineering , backscatter (email) , biological tissue , acoustics , optics , physics , computer science , nanotechnology , medicine , telecommunications , wireless
A theoretical model is described for application in ultrasonic tissue characterization using a calibrated 2‐D spectrum analysis method. This model relates 2‐D spectra computed from ultrasonic backscatter signals to intrinsic physical properties of tissue microstructures, e.g., size, shape, and acoustic impedance. The model is applicable to most clinical diagnostic ultrasound systems. Two experiments employing two types of tissue architectures, spherical and cylindrical scatterers, are conducted using ultrasound with center frequencies of 10 and 40 MHz , respectively. Measurements of a tissue‐mimicking phantom with an internal suspension of microscopic glass beads are used to validate the theoretical model. Results from in vitro muscle fibers are presented to further elucidate the utility of 2‐D spectrum analysis in ultrasonic tissue characterization.