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A 4 × 500 mm 2 cloverleaf detector system for in vivo bone lead measurement
Author(s) -
Fleming David E. B.,
Mills Caitlin E.
Publication year - 2007
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2436973
Subject(s) - imaging phantom , reproducibility , detector , nuclear medicine , lead (geology) , physics , biomedical engineering , materials science , optics , chemistry , medicine , geology , chromatography , geomorphology
A 4 × 500mm 2“cloverleaf” low energy germanium detector array has been assembled for the purpose of in vivo bone lead measurement through x‐ray fluorescence. Using Cd109 as an exciting source, results are reported from a leg phantom simulating measurement of lead in a human tibia. For high activity ( 4.0 – 4.4 GBq ) and low activity ( 0.18 – 0.19 GBq ) sources, measurement results are reported for both the cloverleaf system and a conventional single detector system of equivalent surface area ( 2000mm 2 ) . The mean uncertainty and reproducibility of measurement were both significantly improved for the cloverleaf system with a high activity Cd109 source. When using a source activity of 4.4 GBq , measurement of the phantom resulted in an average bone lead uncertainty of 0.79 μ g ∕ g and a reproducibility of 0.84 μ g ∕ g . These results represent the highest precision yet reported from a bone lead x‐ray fluorescence system.