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Intra‐fraction dose delivery timing during stereotactic radiotherapy can influence the radiobiological effect
Author(s) -
Murphy Martin J.,
Lin PeckSun,
Ozhasoglu Cihat
Publication year - 2007
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2409750
Subject(s) - radiosurgery , cyberknife , radiation therapy , dosimetry , medicine , nuclear medicine , fraction (chemistry) , stereotactic radiotherapy , cumulative dose , dose fractionation , radiology , chemistry , organic chemistry
The sequence of incremental dose delivery during a radiotherapy fraction can potentially influence the radiobiological effect. This would be most noticeable during the long fractions characteristic of hypo‐fractionated stereotactic radiotherapy and radiosurgery. We demonstrate here the spatio‐temporal variation of dose delivery by the CyberKnife to a lung tumor and propose strategies to reduce and/or correct for any resultant dose‐time cytotoxic effects.