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Biological dose volume histograms during conformal hypofractionated accelerated radiotherapy for prostate cancer
Author(s) -
Koukourakis Michael I.,
Abatzoglou Ioannis,
Touloupidis Stavros,
Manavis Ioannis
Publication year - 2007
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2401655
Subject(s) - prostate cancer , radiation therapy , dosimetry , prostate , medicine , radiobiology , nuclear medicine , brachytherapy , cancer , radiology
Radiobiological data suggest that prostate cancer has a low α ∕ β ratio. Large radiotherapy fractions may, therefore, prove more efficacious than standard radiotherapy, while radiotherapy acceleration should further improve control rates. This study describes the radiobiology of a conformal hypofractionated accelerated radiotherapy scheme for the treatment of high risk prostate cancer. Anteroposterior fields to the pelvis deliver a daily dose of 2.7 Gy , while lateral fields confined to the prostate and seminal vesicles deliver an additional daily dose of 0.7 Gy . Radiotherapy is accomplished within 19 days (15 fractions). Dose volume histograms, calculated for tissue specific α ∕ β ratios and time factors, predict a high biological dose to the prostate and seminal vesicles ( 77 – 93 Gy ) . The biological dose to normal pelvic tissues is maintained at standard levels. Radiobiological dosimetry suggests that, using hypofractionated and accelerated radiotherapy, high biological radiation dose can be given to the prostate without overdosing normal tissues.