Premium
Mesh adaptation technique for Fourier‐domain fluorescence lifetime imaging
Author(s) -
Soloviev Vadim Y.
Publication year - 2006
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2362500
Subject(s) - fourier domain , medical imaging , fourier transform , adaptation (eye) , computer science , fluorescence , medical physics , optics , physics , artificial intelligence , mathematics , mathematical analysis
A novel adaptive mesh technique in the Fourier domain is introduced for problems in fluorescence lifetime imaging. A dynamical adaptation of the three‐dimensional scheme based on the finite volume formulation reduces computational time and balances the ill‐posed nature of the inverse problem. Light propagation in the medium is modeled by the telegraph equation, while the lifetime reconstruction algorithm is derived from the Fredholm integral equation of the first kind. Stability and computational efficiency of the method are demonstrated by image reconstruction of two spherical fluorescent objects embedded in a tissue phantom.