z-logo
Premium
Po‐Thur Eve General‐31: Dosimetric Impact of Planning a Boost within a Boost in Permanent Seed Implants
Author(s) -
Beaulieu L,
Aubin S,
Varfalvy N,
Lessard E,
Pouliot J,
Vigneault E,
Martin AG
Publication year - 2006
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2244658
Subject(s) - prostate , prostate cancer , urethra , medicine , nuclear medicine , urology , cancer
Purpose: To investigate the dosimetric impact on the target volume, boost volume (BV) and urethra of performing limited volume boosts in seed implants. Method and Materials: 35 localized prostate cancer patients with detailed biopsy results were treated with permanent seed implants Personalized plans in which BV corresponding to regions of positive biopsy were generated intra‐operatively based on a simulated annealing inverse planning algorithm. The dose objectives are 144 Gy to the prostate with a 3–4 mm margin, 2/3 (1/3) of the prostate covered by 150% (200%) of the prescription dose (PD), urethra V150 less than 10% and D5 should below 220 Gy. Finally, 100% of BV should receive 150% PD (or 216 Gy). Results: Comparing plans without and with BV show no significant change in the number of seeds, needles, prostate V100 and V200. Prostate V150 (D90) show significant differences increasing from 65% (187Gy) to 70% (191Gy). By forcing the coverage of the BV, the 150% isodose lines (which extend outside the prostate) shift inside of the prostate. Small increase in prostate V150 leads to significant increases of the BV V150 from 79% to 94%. BV do not translate to higher urethra doses. Thus multiple seed reconfigurations inside the prostate are achievable to cover BV. Conclusion: Specific areas within the prostate can be boost to receive 150% of the PD with no impact on the urethra. The plans lead essentially to a rearrangement of the seed positions. Potential radiobiological advantages could be obtained at no cost (procedure or time).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here