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SU‐FF‐T‐217: Evaluation and Validation of GATE‐Based Absorbed Dose Calculation for 3D Patient‐Specific Internal Dosimetry
Author(s) -
Williams C,
Burckhardt D,
Engdahl J
Publication year - 2006
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2241137
Subject(s) - dosimetry , collimator , internal dosimetry , monte carlo method , attenuation , nuclear medicine , radiation treatment planning , absorbed dose , voxel , medical physics , medical imaging , correction for attenuation , computer science , physics , medicine , mathematics , radiation therapy , optics , artificial intelligence , radiology , statistics
Purpose: The objective of this study is to validate the use of GATE Monte Carlo simulations to determine patient‐specific dosimetry using quantitative multi‐modality imaging. Method and Materials: Data acquired with the Symbia ™ hybrid SPECT/CT system are reconstructed with Flash‐3D™ and corrected for scatter, collimator detector response and attenuation using a CT attenuation correction method. The voxel‐based CT model is used with GATE to compute 3D dose distributions from the SPECT data. Validation is performed using both simulated SPECT data and anthropomorphic phantoms. Results: Initial validation studies show that GATE, while time consuming, is suitable in dose calculation. Conclusions: The approach presented can be used for radionuclide multi‐modality dosimetry leading to patient‐specific dose calculations for treatment planning.