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SU‐FF‐I‐78: Estimate Standard Uptake Value (SUV) in F18 FDG PET Tumor Imaging
Author(s) -
Luo J
Publication year - 2006
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2240758
Subject(s) - nuclear medicine , standardized uptake value , scanner , lesion , medicine , coronal plane , positron emission tomography , radiology , computer science , artificial intelligence , pathology
Objective: This study was to evaluate factors that may affect SUV in F 18 FDG PET tumor imaging. Method: Twenty patients with single pulmonary nodules and five with multiple nodules were evaluated. Whole body scan was performed one hour post injection of 15 mCi of F 18 FDG on a dedicated PET scanner (Siemens‐CTI Exact). OS‐EM reconstruction was employed. Reconstructed images were then transferred to a Siemens eSoft workstation for image display and analysis. Volume of lesion was adjusted around the hot nodule in the pulmonary area. The ROI was automatically defined by iso‐contour (10%, 25%, 35%, and 50% respectively) and used to calculate activity in Bq/ml, lesion volume and average SUV within the region. 3‐D image fusion started with manual registration based on axial, sagittal and coronal display of the PET and the CT data. The SUVs were calculated using RoI defined by 50% or 25% iso‐contour. The same RoIs were applied to dedicated PET data and to transformed image from PET‐CT fusion. Result: Average lesion size was 3.9 cm 3 at 50% iso‐contour and increased to 5.9 cm 3 when the iso‐contour was 10%. PET SUV measured 4.77 compared with 4.47 from PET CT fusion image with 50% isocontour and 3.36 compared with 3.79 respectively with 25% isocontour for a large lesion in right lung. Lesion volume decreased about 30%. Conclusion: Manually adjusting the iso‐contour to fit the lesion based on visual inspection on PET images demonstrated significant difference between a pre‐set threshold and image guided iso‐contour on the lesion size, activity uptake and the average SUV. Measured SUV and lesion volume (50% isocontour) decreased when the PET CT fusion image was used in comparison with dedicated PET scan.