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In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine MCa35 model
Author(s) -
Winey Brian A.,
Misic Vladimir,
Liao Lydia,
Parker Kevin,
Fenton Bruce M.,
Yu Yan
Publication year - 2006
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2198196
Subject(s) - ultrasound , in vivo , blood stasis , medicine , pathology , cancer , receiver operating characteristic , optical imaging , biomedical engineering , radiology , optics , biology , alternative medicine , microbiology and biotechnology , traditional chinese medicine , physics
Ultrasound‐induced blood stasis has been observed for more than 30 years . Most of the literature has been focused on the health risks associated with this phenomenon and methods employed to prevent stasis from occurring during ultrasound imaging. To date, experimental observations have been either in vitro or invasive. The current work demonstrates ultrasound‐induced blood stasis in murine normal leg muscle versus tumor‐bearing legs, observed through noninvasive measurements of optical spectroscopy, and discusses possible diagnostic uses for this previously undesirable effect of ultrasound. We demonstrate that, using optical spectroscopy, effects of ultrasound can be used to differentiate tumor from normal leg muscle tissue in mice. Finally, we propose a novel diagnostic algorithm that quantitatively differentiates tumor from nontumor with maximum specificity 0.83, maximum sensitivity 0.79, and area under receiver‐operating‐characteristics curve 0.90.