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A Born‐type approximation method for bioluminescence tomography
Author(s) -
Cong Wenxiang,
Durairaj Kumar,
Wang Lihong V.,
Wang Ge
Publication year - 2006
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.2168293
Subject(s) - bioluminescence , imaging phantom , signal (programming language) , bioluminescence imaging , physics , acoustics , optics , computer science , biology , ecology , transfection , genetics , luciferase , programming language , cell culture
In this paper, we present a Born‐type approximation method for bioluminescence tomography (BLT), which is to reconstruct an internal bioluminescent source from the measured bioluminescent signal on the external surface of a small animal. Based on the diffusion approximation for the photon propagation in biological tissue, this BLT method utilizes the Green function to establish a linear relationship between the measured bioluminescent signal and the internal bioluminescent source distribution. The Green function can be modified to describe a heterogeneous medium with an arbitrary boundary using the Born approximation. The BLT reconstruction is formulated in a linear least‐squares optimization framework with simple bounds constraint. The performance of this method is evaluated in numerical simulation and phantom experiments.