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TU‐D‐J‐6B‐01: Small Animal PET and SPECT: Instrumentation, Performance, and Applications
Author(s) -
Levin CS
Publication year - 2005
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1998400
Subject(s) - positron emission tomography , molecular imaging , preclinical imaging , single photon emission computed tomography , medical physics , emission computed tomography , in vivo , nuclear medicine , medicine , pet imaging , biology , microbiology and biotechnology
In recent years both industrial and academic institutions have been intrigued with the possibility of using in vivo imaging assays in small animal models to study cellular and molecular processes associated with diseases such as cancer, heart disease, and neurological disorders. The ultimate goals of these in vivo imaging efforts are to facilitate the discovery of new drugs and treatments for disease and accelerate their translation into the clinic. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are highly sensitive in vivo imaging modalities that can detect extremely low concentrations of radionuclide‐labeled probes that target the disease process of interest at the molecular level. This presentation will review PET and SPECT small animal imaging instrumentation requirements, challenges, performance characteristics, and applications in imaging subtle molecular signals associated with disease.