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T1 measurement using a short acquisition period for quantitative cardiac applications
Author(s) -
Higgins David M.,
Ridgway John P.,
Radjenovic Aleksandra,
Sivananthan U. Mohan,
Smith Michael A.
Publication year - 2005
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1921668
Subject(s) - cardiac cycle , first pass , contrast (vision) , computer science , signal (programming language) , data acquisition , single shot , range (aeronautics) , artificial intelligence , perfusion , nuclear medicine , computer vision , mathematics , biomedical engineering , medicine , physics , radiology , materials science , optics , arithmetic , composite material , programming language , operating system
Myocardial signal intensity curves for myocardial perfusion studies may be made quantitative by the use of T1 measurements made after the first‐pass of contrast agent. A short data acquisition method for T1 mapping is presented in which all data for each T1 map are acquired in a short breath hold, and the slice geometry and timing in the cardiac cycle exactly match that of the dynamic first‐pass perfusion sequence. This allows accurate image registration of the T1 map with the first‐pass series of images. The T1 method is based on varying the preparation‐pulse delay time of a saturation recovery sequence, and in this implementation employs an ECG‐triggered, single‐shot, spoiled gradient echo technique with SENSE reconstruction. The method allows T1 estimates of three slices to be made in fifteen heartbeats. For a range of samples with T1 values equivalent to those found in the myocardium during the first‐pass of contrast agent, T1 estimates were accurate to within 6%, and the variation between slices was 2% or less.