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Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI
Author(s) -
Choe Regine,
Corlu Alper,
Lee Kijoon,
Durduran Turgut,
Konecky Soren D.,
GrosickaKoptyra Monika,
Arridge Simon R.,
Czerniecki Brian J.,
Fraker Douglas L.,
DeMichele Angela,
Chance Britton,
Rosen Mark A.,
Yodh Arjun G.
Publication year - 2005
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1869612
Subject(s) - diffuse optical imaging , breast cancer , magnetic resonance imaging , chemotherapy , medicine , radiology , breast carcinoma , mammography , nuclear medicine , tomography , cancer
We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three‐dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.