Premium
The design and the dosimetry of bi‐nuclide radioactive ophthalmic applicators
Author(s) -
Flühs Dirk,
Anastassiou Gerasimos,
Wening Jan,
Sauerwein Wolfgang,
Bornfeld Norbert
Publication year - 2004
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1755471
Subject(s) - dosimetry , nuclear medicine , radionuclide , nuclide , brachytherapy , medicine , radiation therapy , medical physics , materials science , biomedical engineering , radiology , physics , nuclear physics
A novel type of applicator for the treatment of intra‐ocular tumors has been developed, based on the two radionuclides106 Ru / 106 Rh and125 I . The dose distribution of this ophthalmic plaque combines advantageous features of both radionuclides and can be optimally adapted to a tumor thickness in the range 6.5–9 mm, a size which is beyond the dosimetric limitations of the106 Ru / 106 Rh plaque therapy. Compared with125 I plaques a bi‐nuclide plaque allows to maintain the tumor dosage while the dose in the irradiated volume outside of the target volume is significantly reduced. Consequently, radiosensitive structures within the eye can be spared more effectively. Dedicated methods have been developed for the dosimetry of this plaque. These methods are based on our own extensive dosimetric investigations with plastic scintillators. The precondition was the availability, developed in recent years, of a more accurate determination of the absolute dose rate to water of beta‐ and low energy emitters.