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Improving binding potential analysis in [ 11 C ] raclopride PET studies using cluster analysis
Author(s) -
Glatting Gerhard,
Mottaghy Felix M.,
Karitzky Jochen,
Baune Axel,
Sommer Friedrich T.,
Landwehrmeyer G. Bernhard,
Reske Sven N.
Publication year - 2004
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1668392
Subject(s) - medical imaging , cluster (spacecraft) , nuclear medicine , medical physics , medicine , computer science , radiology , programming language
To calculate binding potentials (BP) in [ 11 C ] raclopride brain PET studies a reference tissue model is widely used. The aim of the present study was to improve the determination of time activity curves (TAC) of reference tissue regions using cluster analysis. In four patients with Huntington disease TACs of a cerebellar reference region were calculated either from manually placed circular ROIs within the cerebellum or by cluster analysis. BP estimates derived from cluster analysis are independent from inter‐ and intraobserver variations and show an improved reproducibility combined with a low variability compared to manually placed cerebellar ROIs. This is of high value in longitudinal studies.