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Stress analysis using anatomically realistic coronary tree
Author(s) -
Wu HsienChih,
Chen S.Y. James,
Shroff Sanjeev G.,
Carroll John D.
Publication year - 2003
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1593635
Subject(s) - myocardial infarction , fibrous cap , cardiology , lesion , thrombosis , medicine , arterial tree , sudden death , unstable angina , acute coronary syndrome , coronary thrombosis , radiology , materials science , pathology
Plaque rupture with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina, myocardial infarction, and sudden death. Endothelial disruption leading to plaque rupture may relate to mechanical fatigue associated with cyclic flexion of plaques. A novel method is proposed to assess stress and strain distribution using the finite element (FE) analysis and in vivo patient‐specific dynamic 3D coronary arterial tree reconstruction from cine angiographic images. The local stresses were calculated on the diseased arterial wall which was modeled as consisting of a central fibrotic cap subjected to the cyclic flexion from cardiac contraction. Various parameters characterizing the plaque were chosen including vessel diameter, percentage narrowing, and lesion length. According to the FEA simulations, the results show that the smaller vessel diameter, greater percentage narrowing, and/or larger lesion size may result in higher stress on the plaque cap, with the vessel diameter as the dominant factor.