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Phase‐contrast imaging of tissue using near‐infrared diffusing light
Author(s) -
Jiang Huabei,
Xu Yong
Publication year - 2003
Publication title -
medical physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.473
H-Index - 180
eISSN - 2473-4209
pISSN - 0094-2405
DOI - 10.1118/1.1574235
Subject(s) - imaging phantom , optics , diffuse optical imaging , refractive index , photon diffusion , heavy traffic approximation , iterative reconstruction , medical imaging , materials science , scattering , optical tomography , phase contrast imaging , light scattering , phase (matter) , tomography , physics , phase contrast microscopy , mathematics , computer science , light source , statistics , quantum mechanics , artificial intelligence
We describe a new model‐based image reconstruction method that can extract the spatial variation of tissue refractive index with near‐infrared diffusing light. The model of light propagation is a diffusion approximation to the radiative transfer equation for highly scattering media with spatially varying refractive index. The spatial map of refractive index is recovered using a finite element‐based Newton‐type reconstruction algorithm. The imaging method is validated using several tissue‐like phantom experiments. Initial in vivo imaging of breast tissue is also presented, demonstrating the ability of this new imaging method for tumor detection.